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Diagnosing non-small cell lung cancer by morphology in small samples(e.g. biopsy, cell block, FNA) can be difficult. In these cases, given that conserving tissue for molecular testing is a priority, an effective immunohistochemistry (IHC)-based diagnostic approach is warranted.
At present, p63 is the most frequently used marker for lung squamous cell carcinoma (SqCC). p63 is extremely sensitive for SqCC; however, it suffers from specificity limitations, due to its reactivity in a subset of lung adenocarcinomas. p40 is a relatively unknown antibody that recognizes ΔNp63, a p63 isoform suggested to be highly specific for squamous/basal cells1. p40 may be a valuable marker inimproving the specificity over p63.
Disclaimer: Biozatix Indonesia adalah distributor yang menyediakan alat-alat laboratorium, alat kesehatan, serta reagensia elisa kits, immunohistochemistry (IHC), antibody, research grade chemical, western blot, HPLC colomn, alat patologi.