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ZytoLight ® SPEC ERBB2/CEN 17 Dual Color Probe
Previously: ZytoLight SPEC HER2/CEN 17 Dual Color Probe
Background The ZytoLight ® SPEC ERBB2/CEN 17 Dual Color Probe is designed for the detection of ERBB2 gene amplification frequently observed in solid malignant neoplasms e.g. breast cancer samples. The ERBB2 gene (a.k.a. HER2 and NEU) is located in the chromosomal region 17q12 and encodes a 185-190 kDa transmembrane glycoprotein, p185, acting as a cellular growth factor receptor. The p185 protein belongs to the EGFR (epidermal growth factor receptor) subgroup of the RTK (receptor tyrosine kinase) superfamily also including ERBB1 (HER1), ERBB3 (HER3), and ERBB4 (HER4). Amplification of the proto-oncogene ERBB2, observed in approximately 20% of all breast cancer samples, has been correlated with a poor prognosis of the disease. Similar results have been obtained for a variety of other malignant neoplasms e.g. ovarian cancer, stomach cancer, and carcinomas of the salivary gland.
Probe Description The SPEC ERBB2/CEN 17 Dual Color Probe is a mixture of an orange fluorochrome direct labeled CEN 17 probe specific for the alpha satellite centromeric region of chromosome 17 (D17Z1) and a green fluorochrome direct labeled SPEC ERBB2 probe specific for the chromosomal region 17q12-q21.1 harboring the ERBB2 gene.
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